5-Amino-1MQ

Description

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue and liver that plays a central role in methylation reactions, NAD+ metabolism, and energy homeostasis regulation. As NNMT activity has been associated with adipogenesis, obesity, and insulin resistance in preclinical models, 5-Amino-1MQ has become an important research tool for metabolic disease laboratories.

Preclinical research into 5-Amino-1MQ has examined its effects on white adipose tissue expansion, adipocyte differentiation, NAD+ and SAM (S-adenosylmethionine) availability, and epigenetic regulation through methylation pathway modulation. Animal studies have investigated its potential role in reducing adipose tissue mass, improving insulin sensitivity markers, and influencing the cellular NAD+/NADH ratio — outcomes with significant implications for metabolic syndrome and obesity biology research.

5-Amino-1MQ has a molecular weight of 190.24 Da and the molecular formula C11H14N2O. CAS number: 1392278-76-0. Unlike most research peptides, 5-Amino-1MQ is a small molecule compound soluble in DMSO and ethanol rather than water. Peptryn’s 5-Amino-1MQ is manufactured to ≥99% purity confirmed by HPLC, with an independent US laboratory COA included with every order.

Storage: Store at -20°C and protect from moisture and light. Soluble in DMSO and ethanol. Not water-soluble.

For laboratory and in vitro research use only. Not intended for human consumption, self-administration, or veterinary use.